Neuroscience

Genetic screen offers new drug targets for Huntington's disease

Using a type of genetic screen that had previously been impossible in the mammalian brain, MIT neuroscientists have identified hundreds of genes that are necessary for neuron survival. They also used the same approach to ...

Alzheimer's disease & dementia

Alzheimer's study shows promise in protecting brain from tau

In the wake of recent disappointments over clinical trials targeting amyloid plaque build-up in Alzheimer's disease, researchers are focusing more attention on misfolded tau protein, another culprit in brain diseases that ...

Oncology & Cancer

More efficient drug delivery within the brain by utilizing LAT1

According to a new study carried out at the University of Eastern Finland, the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain. By converting drug ...

Genetics

Scientists hone in on DNA differences behind immune diseases

Scientists are one step closer to discovering the causes of immune diseases such as asthma, multiple sclerosis and arthritis. Research from the Wellcome Sanger Institute, GSK and Biogen, under the Open Targets initiative, ...

Medical research

Scientists enlist tiny biomagnets for faster drug discovery

What started as a hallway conversation between colleagues is now an "engine for the discovery of new therapeutic targets in cells" thanks to Medicine by Design, says Shana Kelley, a University Professor in the Leslie Dan ...

Medical research

Novel paradigm in drug development

Traditional medicines mostly function as inhibitors, attacking the disease-relevant proteins that cause cancer, by binding to their accessible pockets. Following this strategy, only ~20% of all proteins are chemically addressable, ...

Oncology & Cancer

Targeting cell division in pancreatic cancer

Pancreatic cancer is one of the deadliest cancers, with patients surviving on average less than a year once the disease has spread. There is an urgent need to evaluate more therapeutic targets. The chemotherapeutic agent ...

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