Oncology & Cancer

New cancer drug targets accelerate path to precision medicine

In one of the largest studies of its kind, researchers used CRISPR technology to disrupt every gene in over 300 cancer models from 30 cancer types and discover thousands of key genes essential for cancer's survival. The team, ...

Oncology & Cancer

New nanoparticles that shut off cancer genes shrink tumors in mice

By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted or copied in cancer cells. This treasure trove is a boon for researchers seeking new drug targets, but it is nearly ...

Neuroscience

Genetic screen offers new drug targets for Huntington's disease

Using a type of genetic screen that had previously been impossible in the mammalian brain, MIT neuroscientists have identified hundreds of genes that are necessary for neuron survival. They also used the same approach to ...

Alzheimer's disease & dementia

Alzheimer's study shows promise in protecting brain from tau

In the wake of recent disappointments over clinical trials targeting amyloid plaque build-up in Alzheimer's disease, researchers are focusing more attention on misfolded tau protein, another culprit in brain diseases that ...

Medical research

Scientists enlist tiny biomagnets for faster drug discovery

What started as a hallway conversation between colleagues is now an "engine for the discovery of new therapeutic targets in cells" thanks to Medicine by Design, says Shana Kelley, a University Professor in the Leslie Dan ...

Genetics

Scientists hone in on DNA differences behind immune diseases

Scientists are one step closer to discovering the causes of immune diseases such as asthma, multiple sclerosis and arthritis. Research from the Wellcome Sanger Institute, GSK and Biogen, under the Open Targets initiative, ...

Medical research

Reinvigorating the clinical drug pipeline for TB

A research team led by scientists from the Broad Institute has uncovered a novel group of chemical inhibitors that can kill the bacteria that causes tuberculosis (TB). Importantly, these chemical compounds take aim at a previously ...

page 1 from 23