Medical research

Novel paradigm in drug development

Traditional medicines mostly function as inhibitors, attacking the disease-relevant proteins that cause cancer, by binding to their accessible pockets. Following this strategy, only ~20% of all proteins are chemically addressable, ...

Alzheimer's disease & dementia

New drug targets early instigator of Alzheimer's disease

Over a hundred years after they were first identified, two ominous signposts of Alzheimer's disease (AD) remain central topics of research—both formed by sticky accumulations of protein in the brain. Amyloid beta solidifies ...

Alzheimer's disease & dementia

Novel PET staging system may help monitor Alzheimer disease

(HealthDay)—A staging system of β-amyloid (Aβ) accumulation may be useful for monitoring patients throughout the course of Alzheimer disease (AD), according to a study published online July 17 in JAMA Neurology to coincide ...

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