Behind the term ectodermal dysplasia lies a wide range of genetic disorders that can have a major impact on patients' lives and quality of life. Some cannot sweat, others are born with missing or cone-shaped teeth, while ...
Apr 2, 2024
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A McGill-led team of researchers has made an important discovery shedding light on the genetic basis of a rare skeletal disorder. The study, published in Nature Communications, reveals that a defect in a specific gene (heterozygous ...
Jan 16, 2024
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An international team of 100 researchers at 70 sites in 17 countries has found no reduction in death for treatment guided by cerebral oximetry monitoring in extremely preterm infants.
When it comes to height, our fate is sealed along with our growth plates—cartilage near the ends of bones that hardens as a child develops. Research published April 14 in the journal Cell Genomics shows that cells in these ...
Apr 14, 2023
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A clinical trial at the National Institutes of Health found that a medication, denosumab, significantly reduced abnormal bone turnover in adults with fibrous dysplasia, a rare disease marked by weak and misshapen bones. Bone ...
Apr 5, 2023
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To perform coordinated movements, we rely on special sensory neurons in our muscles and joints. Without them, the brain wouldn't know what the rest of our body was doing. A team led by Niccolò Zampieri has studied their ...
Dec 9, 2022
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A recently published study reveals new insights into how gastric cancer develops and suggests a preventive treatment.
Jul 1, 2022
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Medical researchers are a big step closer to understanding the inflammatory responses in pre-term babies that can cause devastating heart and lung conditions including bronchopulmonary dysplasia (BPD) and pulmonary hypertension ...
Apr 6, 2022
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One of the serious complications that can occur during late pregnancy happens when the amniotic sac (also called the bag of waters) breaks too early, which can allow bacterial infections to cause dangerous tissue inflammation ...
Mar 30, 2022
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Mesomelic dysplasias are a group of rare genetic conditions characterized by extreme shortening of the long bones in the arms and legs. Despite several decades of research on these conditions, the exact cause of mesomelic ...
Aug 23, 2021
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Dysplasia (from the Greek δυσπλασία "malformation", δυσ- "mal-" + πλάθω "to create, to form"), is a term used in pathology to refer to an abnormality of development. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells. Dysplasia is often indicative of an early neoplastic process. The term dysplasia is typically used when the cellular abnormality is restricted to the originating tissue, as in the case of an early, in-situ neoplasm.
Dysplasia, in which cell maturation and differentiation are delayed, can be contrasted with metaplasia, in which cells of one mature, differentiated type are replaced by cells of another mature, differentiated type.
The terms hip dysplasia and fibrous dysplasia also refer to abnormal development, but at a more macroscopic level.
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