Medical research

Base editors flex sights on sickle-cell disease

Researchers at Beam Therapeutics have developed a redesigned base editor that shows considerable promise in directly repairing the single-base mutation that causes sickle-cell disease (SCD). Many strategies are being pursued ...

Health

Advice for Canada's new health minister

Enact a national pharmacare program for Canadians. Let science and evidence guide health policy. Keep your promises. These are some of the recommendations that the editors of Canada's major medical journal, CMAJ (Canadian ...

Medical research

Can toxicity of a DNA drug be predicted and minimized?

New classes of therapeutic antisense oligonucleotides can have toxic effects on the liver. A novel machine learning-based approach used to predict the hepatotoxic potential of an antisense drug based on its chemical sequence ...

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