Genetics

Decoding the language of epigenetic modifications

Epigenetic changes play important roles in cancer, metabolic and aging-related diseases, but also during loss of resilience as they cause the genetic material to be incorrectly interpreted in affected cells. A major study ...

Arthritis & Rheumatism

How to rewind the clock on arthritic cartilage

A new study in Aging Cell describes how a key protein called Signal Transducer and Activator of Transcription 3 (STAT3) might turn back the clock on aging cartilage that leads to osteoarthritis.

Oncology & Cancer

Scientists prevent 'exhaustion' in cancer-fighting T cells

When faced with a formidable foe for months on end, the immune system's T cells begin to tire. Whether fighting a cancer or a chronic infection, they become less effective over time, a phenomenon dubbed "T cell exhaustion" ...

Oncology & Cancer

Exposing cancer's metabolic addictions

Cancerous tumors are classified primarily based on their tissue of origin. However, the sequencing of the human genome and the development of powerful and affordable DNA sequencing technologies has ushered in a new era of ...

Genetics

Researchers relate DNA methylation levels to obesity

DNA methylation is a mechanism that regulates whether genes are "on" or "off", and is influenced by hereditary and environmental factors, as well as lifestyle and nutritional habits.

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