Estrogen receptor positive (ER+) breast cancer is the most common type of breast cancer, but resistance to therapy is common and eventual development of metastatic disease is a leading cause of death. In new research published ...
Aug 8, 2018
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Essential processes in mammalian cells are controlled by proteins called transcription factors. For example, the transcription factor HIF-1 is triggered by a low-oxygen situation to cause the cell to adapt to decreased oxygen.
Jun 3, 2020
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(Medical Xpress)—The medial preoptic area of the brain has been found over the years to be very closely involved with certain behaviors in mice, such as sexual proclivity, locomotion, aggression and the motivation to care ...
When a woman becomes pregnant, her levels of estriol, one of the three common estrogens that are nearly undetectable before conception, skyrocket. However, scientists never knew what this hormone does or why levels of it ...
May 5, 2022
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Becoming pregnant after a diagnosis of breast cancer does not raise the risk of the cancer returning, said the largest study of its kind to date, released Saturday at a major cancer conference.
Jun 4, 2017
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Men are four times more likely to develop liver cancer compared to women, a difference attributed to the sex hormones androgen and estrogen. Although this gender difference has been known for a long time, the molecular mechanisms ...
Jan 19, 2012
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University of Houston (UH) researchers have their sights set on developing possible treatments for breast and colon cancer.
Aug 22, 2011
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Advanced or metastatic estrogen receptor-positive (ER+) breast cancer is commonly treated with drugs that block the estrogen receptor. However, estrogens that stimulate the receptor can also be effective. Building on their ...
May 15, 2023
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An animal study suggests that resistance to tamoxifen therapy in some estrogen receptor positive breast cancers may originate from in utero exposure to endocrine disrupting chemicals. The study provides a new path forward ...
Sep 8, 2016
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Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences have found that the breast cancer drug tamoxifen gives white blood cells a boost, better enabling ...
Oct 13, 2015
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