An international group of clinicians and scientists representing the Clinical Pharmacogenetics Implementation Consortium (CPIC) published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen ...
Feb 1, 2018
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(Medical Xpress)—A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive ...
Nov 2, 2012
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(HealthDay)—Researchers have identified genes that may help predict whether a patient with estrogen receptor (ER)-positive breast cancer is likely to benefit from tamoxifen therapy, according to a study published in the ...
Jul 22, 2014
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Researchers at Stevens Institute of Technology and colleagues have designed and developed a new class of molecules that use a never-before-known mechanism that may halt or destroy breast cancer tumors, particularly for patients ...
Oct 3, 2018
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Fluctuations in the hormones secreted by women's ovaries, namely estrogen and progesterone, are known to cause mood swings. For instance, at different points of the menstrual cycle, during or after pregnancy and while reaching ...
Breast cancer researchers have discovered that mutations found outside of genes that accumulate in estrogen receptor positive breast tumours throughout their development act as dominant culprits driving the disease.
Aug 29, 2016
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Binge eating, an eating disorder in which a person frequently consumes unusually large amounts of food in a short period of time, affects about 5 to 10 percent of U.S. adults and is more common in women than men. Researchers ...
Aug 26, 2014
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A research paper published today in The Lancet Oncology demonstrates that the drug enobosarm, a selective androgen receptor modulator that stimulates the male sex hormone receptor, has anti-tumor effects in estrogen receptor-positive ...
Feb 8, 2024
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UCLA researchers demonstrated that loss of a key protein that regulates estrogen and immune activity in the body could lead to aspects of metabolic syndrome, a combination of conditions that can cause Type 2 diabetes, atherosclerosis ...
Sep 6, 2011
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Metastatic breast cancers treated with hormone therapy can become treatment-resistant when they acquire mutations in the human epidermal growth factor receptor 2 (HER2) that were not present in the original tumor, reports ...
Dec 11, 2018
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