Health

BPA affects sex-based behavior in mice

(Medical Xpress)—Bisphenol A (BPA) is a common chemical found in household plastics. Previous studies on rodents show that BPA exposure is associated with problems with brain and behavioral development. There is evidence ...

Medical research

New discovery in breast cancer treatment

Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease.

Oncology & Cancer

Mutation leading to biological changes may play role in cancer

A new study from McGill University's Goodman Cancer Research Center (GCRC) has revealed significant biological changes in mice expressing an activated, mutant form of the Estrogen Receptor alpha (ER alpha), shedding new light ...

Medical research

'Terminator' protein halts cancer-causing cellular processes

Essential processes in mammalian cells are controlled by proteins called transcription factors. For example, the transcription factor HIF-1 is triggered by a low-oxygen situation to cause the cell to adapt to decreased oxygen.

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Estrogen receptor

Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. This article refers to the nuclear hormone receptor ER.

The main function of the estrogen receptor is as a DNA binding transcription factor that regulates gene expression. However, the estrogen receptor has additional functions independent of DNA binding.

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