Obstetrics & gynaecology
How does a baby 'breathe' while inside its mom?
"Mothering" is synonymous with "nurturing," probably because moms start providing for their kids even before they're born.
May 5, 2020
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News tagged with fetal hemoglobin
Medical research
Gene therapy to boost fetal hemoglobin continues to do well in sickle cell trial
A pilot gene therapy treatment for sickle cell disease, restoring patients' ability to make fetal hemoglobin, has produced good results in the first three patients to receive it. Investigators at Boston Children's Hospital ...
Jan 10, 2020
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Medical research
Targeting a blood stem cell subset shows lasting, therapeutically relevant gene editing
In a paper published in the July 31 issue of Science Translational Medicine, researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed ...
Jul 31, 2019
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Medical research
Enzyme identified as possible novel drug target for sickle cell disease, Thalassemia
Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease (SCD). Experiments ...
Jul 19, 2018
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Obstetrics & gynaecology
Study provides insights on preeclampsia
Researchers have developed a method that could help rapidly diagnose preeclampsia in pregnant women. They have also uncovered clues that might help explain why women with preeclampsia often develop an abnormal amount of protein ...
Jul 20, 2017
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Medical research
Fighting sickle cell disease using a medication for type 2 diabetes
Sickle cell disease and the blood disorder beta thalassemia affect more than 180,000 Americans and millions more worldwide. Both diseases can be made milder or even cured by increasing fetal hemoglobin (HbF) levels, but current ...
Jan 11, 2017
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Medical research
BCL11A-based gene therapy for sickle cell disease passes key preclinical test
A precision-engineered gene therapy virus, inserted into blood stem cells that are then transplanted, markedly reduced sickle-induced red-cell damage in mice with sickle cell disease, researchers from Dana-Farber/Boston Children's ...
Sep 6, 2016
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Medical research
CRISPR gene editing reveals new therapeutic approach for blood disorders
An international team of scientists led by researchers at St. Jude Children's Research Hospital has found a way to use CRISPR gene editing to help fix sickle cell disease and beta-thalassemia in blood cells isolated from ...
Aug 15, 2016
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Medical research
Discovery could help treatments for sickle cell disease
An interdisciplinary, international group of researchers has found new biophysical markers that could help improve the understanding of treatments for sickle cell disease, a step toward developing better methods for treating ...
Aug 8, 2016
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Medical research
Multiple myeloma drug could revolutionize treatment for sickle cell disease
An established drug for recurrent multiple myeloma might effectively be repurposed to improve the survival and day-to-day lives of patients with devastating sickle cell disease, according to revealing new research by a Feinstein ...
Dec 17, 2015
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