Immunology

Research reveals how a fungal infection activates inflammation

Scientists at St. Jude Children's Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus. Fungal infection, especially with A. fumigatus, ...

Diseases, Conditions, Syndromes

Clostridium difficile infections may have a friend in fungi

The pathogen Clostridium difficile, which causes one of the most common hospital-acquired infections in the United States, may have accomplices that until now have gone largely unnoticed.

Diseases, Conditions, Syndromes

Understanding C. auris transmission with the healthcare environment

Researchers have now shown that patients who are heavily colonized with Candida auris on their skin can shed the fungus and contaminate their surroundings. This finding provides an explanation for the extensive contamination ...

Immunology

CRISPR reveals the secret life of antimicrobial peptides

When it comes to the immune system, we usually think about lymphocytes like B and T cells or macrophages going on constant seek-and-destroy missions against invading pathogens like bacteria and viruses. But our immune system ...

Diseases, Conditions, Syndromes

Off-patent drug appears promising as broad-spectrum antifungal

By screening a library of off-patent drugs, scientists have identified a compound with promising broad-spectrum antifungal activity. The compound, alexidine dihydrochloride, warrants further development as a pan-fungal, anti-biofilm ...

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