Oncology & Cancer

Early genome catastrophes can cause non-smoking lung cancer

Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related ...

Oncology & Cancer

CRISPR catches out critical cancer changes

In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have ...

Psychology & Psychiatry

Researchers have identified the first human-specific fusion gene

University at Buffalo researchers have identified the first human-specific fusion gene—a hybrid of two genes—implicated in Alzheimer's disease. The finding suggests that a neurotransmitter receptor, previously successful ...

Oncology & Cancer

A more accurate method to diagnose cancer subtypes

Developed by researchers at the Garvan Institute of Medical Research, this potential diagnostic method screens a cancer sample for 'fusion genes', estimated to be linked to one in five cancers, and may provide a more accurate ...

Medical research

Making 'sense' of the 'cart before the horse' in mammalian cells

A fusion gene is a new gene made by joining parts of two different genes. The current thought is that fusion genes can happen in cells with unstable genome when part of the DNA from one chromosome moves to another chromosome. ...

Oncology & Cancer

Scientists map the genetic evolution of childhood leukaemia

The key genetic events responsible for initiating the early stages of a type of childhood leukaemia have been identified by scientists at The Institute of Cancer Research, London. Insights into the 'founder' genetic mutation ...

Oncology & Cancer

Gene fusion shifts cell activity into high gear, causing some cancer

The fusion of two adjacent genes can cause cancer by kicking mitochondria into overdrive and increasing the amount of fuel available for rampant cell growth, researchers at Columbia University Medical Center (CUMC) have discovered. ...

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