Researchers from Hefei University of Technology in China have recently published an exhaustive review in the Journal of Medicinal Chemistry on emerging roles of small kinase inhibitors in the treatment of diseases. In contrast ...
Scientists at Scripps Research have clarified the workings of a mysterious protein called Gαo, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders.
Feb 3, 2021
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G protein-coupled receptors (GPCRs) are the largest family of membrane protein receptors. The proteins control how tissues and organs function. More than one-third of current drugs target these receptors.
Nov 5, 2020
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Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.
Oct 2, 2020
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Duke University researchers have developed a synthetic molecule that selectively dampen the physiological rewards of cocaine in mice. It also may represent a new class of drugs that could be more specific with fewer side ...
May 28, 2020
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Mutations in a vital class of regulatory molecules are an underappreciated cause of cancer because they impair the function of "G" proteins, a versatile and vast family of signaling switches that underlie innumerable biological ...
An LMU team has clarified how a receptor which is involved in the regulation of vital physiological processes senses the mechanical forces that act on blood vessels. The findings could suggest new therapies for diseases of ...
Jan 31, 2020
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New research from Cornell University details how two highly lethal viruses have greater pathogenic potential when their proteins are combined.
Aug 13, 2019
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Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout ...
May 20, 2019
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Johns Hopkins Medicine scientists say that new experiments with mouse eye tissues strongly suggest that a longstanding "textbook concept" about the way a mammal's retina processes light needs a rewrite.
May 16, 2019
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