Oncology & Cancer

CICERO software enables detection of cancer-causing gene fusions

After years of development, engineering and enhancement, researchers at St. Jude Children's Research Hospital have made publicly available a software system that enables better detection of gene fusions. The system, called ...

Medical research

Researchers develop new database of druggable fusion targets

When sections from two separate genes merge due to various factors, such as translocation or splicing, the hybrid that is formed is called a gene fusion. In recent years, it has been discovered that these fusion events play ...

Oncology & Cancer

Early genome catastrophes can cause non-smoking lung cancer

Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related ...

Psychology & Psychiatry

Researchers have identified the first human-specific fusion gene

University at Buffalo researchers have identified the first human-specific fusion gene—a hybrid of two genes—implicated in Alzheimer's disease. The finding suggests that a neurotransmitter receptor, previously successful ...

Oncology & Cancer

CRISPR catches out critical cancer changes

In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have ...

Oncology & Cancer

A more accurate method to diagnose cancer subtypes

Developed by researchers at the Garvan Institute of Medical Research, this potential diagnostic method screens a cancer sample for 'fusion genes', estimated to be linked to one in five cancers, and may provide a more accurate ...

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