Oncology & Cancer

Why do the majority of people never get cancer?

(PhysOrg.com) -- Every year, millions of people are diagnosed with cancer - a remarkably high number. But what about the flipside of those statistics? That is, two out of three people never get cancer, and more than half ...

Diseases, Conditions, Syndromes

Hepatitis C virus genotype 1 is most prevalent worldwide

In one of the largest prevalence studies to date, researchers from the U.K. provide national, regional, and global genotype prevalence estimates for the hepatitis C virus (HCV). Findings published in Hepatology, a journal ...

Diseases, Conditions, Syndromes

1 in 3000 blood donors in England infected with hepatitis E

The first systematic analysis of hepatitis E virus (HEV) transmission by blood components indicates that about 1 in 3000 donors in England have HEV in their plasma. The findings, published in The Lancet, suggest that around ...

Diabetes

CYP2C19 polymorphisms impacts citalopram metabolism

(HealthDay)—For patients with major depressive disorder, certain CYP2C19 polymorphisms contribute to citalopram (CIT) metabolism, according to research published in the December issue of the Journal of Clinical Pharmacy ...

Medications

Alcohol use curbed by anti-nausea medication, study finds

Alcoholics who were given a medication approved for quelling nausea were able to cut back on their alcohol intake, researchers reported this week. The medication, ondansetron (Zofran), could become a readily available therapy ...

Diseases, Conditions, Syndromes

Researchers trace source of cocaine-driven TB outbreak

(PhysOrg.com) -- Simon Fraser University researchers are the first to combine the latest techniques of whole bacterial genome analysis with social networking surveys to track down the puzzling origins of a tuberculosis (TB) ...

Diseases, Conditions, Syndromes

Even light drinkers should watch for fatty liver disease

People who have reduced enzyme activity to breakdown active aldehyde, i.e., those who become easily inebriated, are more likely to develop fatty liver disease even if they do not drink alcohol. This discovery was made by ...

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Genotype

The genotype is the genetic constitution of a cell, an organism, or an individual (i.e. the specific allele makeup of the individual) usually with reference to a specific character under consideration. For instance, the human albino gene has two allele forms, dominant A and recessive a, and there are three possible genotypes- AA (homozygous dominant), Aa (heterozygous), and aa (homozygous recessive).

It is a generally accepted theory that inherited genotype, transmitted epigenetic factors, and non-hereditary environmental variation contribute to the phenotype of an individual.

Non-hereditary DNA mutations are not classically understood as representing the individual's genotype. Hence, scientists and physicians sometimes talk for example about the (geno)type of a particular cancer, that is the genotype of the disease as distinct from the diseased.

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