Genetics

How stress in the intestine influences chromosome inheritance

Inheriting a normal and intact number of chromosomes in germ cells, egg and sperm, is essential for the preservation of all species. With increasing age, the risk of the egg cell not inheriting the normal set of chromosomes ...

Neuroscience

How retrotransposons control the brain

Around half of the genome is made up of transposable elements or 'jumping genes' that derive from ancient viral integrations. They persist in various states of decay like an old fashioned 'pull your own' junkyard where parts ...

Medical research

Manufacturing spermatogonia stem cells

For species that rely on sexual reproduction, including mice and men, offspring can only happen if sperm from the male fertilize eggs from the female. Even artificial fertilization techniques depend on donors for both of ...

Oncology & Cancer

Genetic study of liver cancer reveals new drug target

Drugs targeting the gene MAGEA3 may help block the growth of hepatocellular carcinoma (HCC), the most common type of primary liver cancer and one of the leading causes of cancer deaths in the country. That's one conclusion ...

Oncology & Cancer

Sperm development linked to testicular cancer

Testicular cancer is the most common type of cancer to affect men between the ages of 15 and 49, and around 95% of these cases are caused by testicular germ cell tumors. Although testicular germ cell tumors typically manifest ...

Gerontology & Geriatrics

How age affects male fertility

In 2012, proud dad Ramjit Raghav made global headlines when he became a father at the age of 96. He had beaten the record for the world's oldest dad—a record he'd set himself, two years earlier, at the age of 94.

Psychology & Psychiatry

Early trauma influences metabolism across generations

People who live through traumatic experiences in childhood often suffer long-lasting consequences that affect their mental and physical health. But moreover, their children and grandchildren can also be impacted as well. ...

Medical research

How an egg cell's 'operating manual' sets the stage for fertility

Recently published work from Carnegie's Allan Spradling and Wanbao Niu revealed in unprecedented detail the genetic instructions immature egg cells go through step by step as they mature into functionality. Their findings ...

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