Evidence of a pan-tissue decline in stemness during human aging
A new research paper was published on the cover of Aging, entitled, "Evidence of a pan-tissue decline in stemness during human aging."
Apr 16, 2024
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A new research paper was published on the cover of Aging, entitled, "Evidence of a pan-tissue decline in stemness during human aging."
Apr 16, 2024
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The hematopoietic system is a complex tissue characterized by multiple layers of stem cells, progenitor cells, and mature blood cells. Operating under normal conditions, it ensures a continuous and stable blood supply throughout ...
Apr 10, 2024
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A key mechanism controlling how bone marrow stem cells work has been revealed in a new study, shining a light on the principles of stem cell biology and opening the door to new therapeutic pathways.
Apr 4, 2024
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Planes, trains, boats, automobiles and even feet. During the past decades and centuries, global travel and human migration have made all of us more worldly—from our broadening awareness of the world beyond our birthplaces, ...
Mar 27, 2024
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A new research paper titled "ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells" has been published in Oncotarget.
Mar 25, 2024
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A method that enhances the functionality of an often-overlooked type of stem cell could lead to better treatments for blood-related diseases, according to new research.
Mar 14, 2024
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For thousands of Americans each year, a bone marrow transplant has the potential to cure diseases such as leukemias, lymphomas, and immune deficiency disorders. While lifesaving, bone marrow transplants are taxing procedures ...
Mar 12, 2024
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As people age or become ill, their immune systems can become exhausted and less capable of fighting off viruses such as the flu or COVID-19. In a new mouse study published in Science Advances, researchers from the USC Stem ...
Jan 26, 2024
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Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) can cure hematopoietic diseases, such as acute myeloid leukemia. Cord blood transplantation (CBT), which accounts for more than one-third of allo-HSCTs in Japan, ...
Jan 24, 2024
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Radon, a naturally occurring radioactive gas produced when metals like uranium or radium break down in rocks and soil, is a known cause of lung cancer. Now, new research has found exposure to high levels of this indoor air ...
Jan 3, 2024
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Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.
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