Medical research

Antibody could increase cure rate for blood, immune disorders

An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at ...

Medical research

Vitamin D and immune cells stimulate bone marrow disease

The bone marrow disease myelofibrosis is stimulated by excessive signaling from vitamin D and immune cells known as macrophages, reveals a Japanese research team. These findings could help to develop alternative treatments ...

Medical research

Scientists generate functional, transplantable B cells from mice

Functional B-1 cells derived from mouse embryonic stem cells are capable of long-term engraftment and secrete natural antibodies after transplantation in mice, researchers report February 7th in the journal Stem Cell Reports. ...

Medical research

Stem cell transplant slows progression of multiple sclerosis

(HealthDay)—For patients with relapsing-remitting multiple sclerosis (MS), nonmyeloablative hematopoietic stem cell transplantation (HCST) is associated with prolonged time to disease progression compared with disease-modifying ...

Medical research

Scientists have identified a bone marrow backup system

New research from the Stowers Institute for Medical Research has identified the backup for an important biological system—the hematopoietic system, whose adult stem cells constantly replenish the body's blood supply.

Medical research

Cohesin down-regulation drives hematopoietic stem cell aging

Aging is characterized by increases in inflammation and decreases in stem cell function. The relationship between these processes remains incompletely understood. Researchers of the Leibniz Institute on Aging (FLI) in Jena, ...

Medical research

Some blood cells have a surprising source—your gut

The human intestine may provide up to 10 percent of blood cells in circulation from its own reservoir of blood-forming stem cells, a surprising new study from researchers at Columbia University Vagelos College of Physicians ...

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Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.

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