Diabetes

NAFLD linked to unfavorable metabolic profile in T2DM

(HealthDay)—For obese patients with type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD) is associated with an unfavorable metabolic profile, according to a study published online Feb. 9 in Diabetes ...

Diabetes

Short-chain fatty acids in diet stimulate fat utilization

(HealthDay)—Short-chain fatty acids (SCFAs), the main products of dietary fiber fermentation, induce a peroxisome proliferator-activated receptor (PPAR) γ-dependent switch from lipid synthesis to lipid utilization, according ...

Diabetes

How does DPP-4 inhibition affect liver function?

(HealthDay)—Dipeptidyl peptidase-4 (DPP-4) inhibition may attenuate hepatic steatosis and insulin resistance induced by the Western diet (WD) through hepatic lipid remodeling and modulation of hepatic mitochondrial function, ...

Diseases, Conditions, Syndromes

Why severe fatty liver leads to liver damage

In hepatic steatosis, hepatocytes "die," resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes ...

Diseases, Conditions, Syndromes

Fatty liver disease and scarring have strong genetic component

Researchers at the University of California, San Diego School of Medicine say that hepatic fibrosis, which involves scarring of the liver that can result in dysfunction and, in severe cases, cirrhosis and cancer, may be as ...

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