In the human body, there is a soft spot—the Achilles tendon. As its name suggests, the Achilles tendon is one of the most powerful and fragile tendons in the body. The Achilles tendon can endure a load close to 8 times ...
Jan 17, 2022
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Blocking a molecule that draws sensory nerves into musculoskeletal injuries prevents heterotopic ossification (HO), a process in which bone abnormally grows in soft tissue during healing, UT Southwestern researchers reported ...
Nov 4, 2021
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Heterotopic ossification (HO) is the formation of bone within soft tissue such as muscle, leading to pain and potentially the inability to use a limb. Once thought to be primarily a genetic disease, the cause of most trauma-induced ...
Apr 15, 2019
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Hip replacements, severe burns, spinal cord injuries, blast injuries, traumatic brain injuries—these seemingly disparate traumas can each lead to a painful complication during the healing process called heterotopic ossification. ...
Feb 6, 2020
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The U.S. Food and Drug Administration (FDA) recently approved palovarotene (Sohonos) as the first treatment for fibrodysplasia ossifcans progressiva (FOP), a severely disabling condition that causes abnormal bone formation ...
Oct 2, 2023
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Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona (UB) have described the ability of an inhibitor of the PI3Kα (BYL719) to block the ectopic bone formation in mice. This ...
Aug 2, 2019
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In a new study published in Bone Research, a team of researchers from Johns Hopkins University and colleagues, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), has delved into the contribution ...
Aug 1, 2023
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A research team led by CiRA Professor Junya Toguchida in collaboration with Assistant Professor Yonghui Jin and graduated student Liping Sun at the Institute for Life and Medical Sciences, Kyoto University, has identified ...
Mar 18, 2024
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A team of researchers led by Associate Professor Makoto Ikeya (Department of Clinical Application) has observed early signs of success from providing iPSC-derived mesenchymal stem/stromal cells (iMSCs) instructions to produce ...
Mar 27, 2024
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