The complete set of nucleic acid sequences composing chromosomes in humans, encoded as DNA, is known as the "human genome sequence." Neuroscientists predict that approximately 25% of this sequence has a regulatory function, ...
The diagnosis is rare, but devastating—children with congenital muscle disorders often never learn to walk. Until now, there was no chance of recovery, but researchers at the University of Basel and University Hospital ...
Mar 29, 2022
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Mutations in a histone regulator protein are linked to both a rare neurodevelopmental disorder and to some cancers, according to a study published in the journal Genes and Development.
Dec 17, 2021
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The neocortex is organized into six neuronal layers and numerous functional areas. They form the structural basis for the processing of sensorimotor stimuli and many of our intellectual abilities. In the course of evolution, ...
Sep 16, 2021
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A gene called DOT1L appears to play a role in progression and severity of ovarian cancer, and inhibitors of the DOT1L enzyme may offer a new therapeutic approach for the disease, University of Alabama at Birmingham researchers ...
Aug 5, 2021
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Researchers at The Australian National University (ANU) have discovered how a DNA-binding protein sustains Hodgkin lymphoma.
Jul 21, 2021
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An epigenetic study at the RIKEN Center for Integrative Medical Sciences shows that in mouse egg cells, modifications to histone H2A at lysine 119 lay the groundwork for inherited DNA functional modifications from the mother.
Apr 7, 2021
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Through an analysis of cellular components (cell fractions) from malignant ascites (fluid buildup in the abdomen caused by gastric cancer), a research collaboration based in Kumamoto University (Japan) has demonstrated that ...
Mar 23, 2021
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Researchers in the Muir Lab at Princeton University's Department of Chemistry have completed the first comprehensive analysis of cancer-associated histone mutations in the human genome, featuring both biochemical and cellular ...
Mar 1, 2021
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How do cis-regulatory genome elements regulate gene expression, what are the critical components involved, and can we therapeutically target them? By investigating how corepressors modulate enhancers and silencers during ...
Jan 27, 2021
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