Oncology & Cancer

Characterization of mutational 'coldspots' in the cancer genome

Mutations are the changes in the DNA that gradually occur in human cells as they replicate, and the organism grows and ages. Some of these changes, particularly when they occur in genes, can be instrumental during the development ...

Genetics

Researchers explore role of androgens in shaping sex differences

Sex differences are widespread across human development, physiological processes, and diseases, making it important to characterize the impact of sex differences in these areas. Understanding the regulatory mechanisms associated ...

Genetics

New atlas of mRNA variants captures inner workings of the brain

Investigators at Weill Cornell Medicine have assembled the most comprehensive atlas to date of messenger RNA (mRNA) variants in the mouse and human brain. The atlas is an important new resource in understanding brain development, ...

Alzheimer's disease & dementia

Human neuron model paves the way for new Alzheimer's therapies

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer's disease ...

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