Kidney organoids provide a promising platform in vitro to model the mechanisms of kidney disease, however, they are limited by an existing lack of knowledge of their inherent functional protein expression. In a new report ...
A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease.
The human brain is probably the most complex organ in the entire living world and has long been an object of fascination for researchers. However, studying the brain, and especially the genes and molecular switches that regulate ...
Oct 7, 2022
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Brain organoids—three-dimensional balls of brain-like tissue grown in the lab, often from human stem cells—have been touted for their potential to let scientists study the formation of the brain's complex circuitry in ...
Jan 29, 2020
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In recent years, researchers have created mini-organs known as organoids in the culture dish that contain many of the cell types and complex microarchitectures found in human organs, such as the kidney, liver, intestine, ...
Feb 11, 2019
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Scientists working to develop more effective treatments for diabetes are turning to stem cells. Such cells can be transformed into cells that produce insulin, the hormone that controls blood sugar.
Jan 17, 2019
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Mutations of the alkaline phosphatase (ALPL) gene in the liver, bone and kidney can cause hypophosphatasia (HPP) and early-onset bone dysplasia, asserting its key role in human bone development. Despite its importance, its ...
Human immune cells in blood can be converted directly into functional neurons in the laboratory in about three weeks with the addition of just four proteins, researchers at the Stanford University School of Medicine have ...
Jun 4, 2018
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One of the liveliest debates in neuroscience over the past half century surrounds whether the human brain renews itself by producing new neurons throughout life, and whether it may be possible to rejuvenate the brain by boosting ...
Mar 7, 2018
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Biomedical engineers have grown the first functioning human skeletal muscle from induced pluripotent stem cells.
Jan 9, 2018
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