Genetics

Novel gene identified as genetic cause of portal hypertension

The liver serves many critical functions within the human body, including the production of critical proteins, and the removal of waste and toxins. But when damage occurs to the largest organ in the body, many people do not ...

Neuroscience

Who is affected by brain pressure disorder the most?

Black and Hispanic women may be more likely than white women to have a brain pressure disorder called idiopathic intracranial hypertension, according to a study published in the May 12, 2021, online issue of Neurology, the ...

Cardiology

Congenital heart disease surgery tied to later hypertension

(HealthDay)—The incidence of hypertension is 12 times higher in children with surgical repair of congenital heart disease (CHD) versus healthy, matched children without CHD, according to a study published online April 8 ...

Genetics

Genetic ancestry and hypertension risk

Black individuals have higher rates of hypertension compared to Americans of European or Hispanic ancestry. Yet the contributions of genetic ancestry to this ethnic disparity in hypertension risk are not well known.

Diseases, Conditions, Syndromes

Portopulmonary hypertension in patients with chronic liver disease

Portopulmonary hypertension (PoPH) is a form of pulmonary arterial hypertension (PAH). PoPH occurs in approximately 15% of patients with PAH, and is reportedly found in 2-6% of patients with portal hypertension and 1-2% of ...

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Hypertension

Hypertension, also referred to as high blood pressure, HTN or HPN, is a medical condition in which the blood pressure is chronically elevated. In current usage, the word "hypertension" without a qualifier normally refers to systemic, arterial hypertension.

Hypertension can be classified as either essential (primary) or secondary. Essential hypertension indicates that no specific medical cause can be found to explain a patient's condition. About 90-95% of hypertension is essential hypertension. Secondary hypertension indicates that the high blood pressure is a result of (i.e., secondary to) another condition, such as kidney disease or tumours (adrenal adenoma or pheochromocytoma).

Persistent hypertension is one of the risk factors for strokes, heart attacks, heart failure and arterial aneurysm, and is a leading cause of chronic renal failure. Even moderate elevation of arterial blood pressure leads to shortened life expectancy. At severely high pressures, defined as mean arterial pressures 50% or more above average, a person can expect to live no more than a few years unless appropriately treated. Beginning at a systolic pressure (which is peak pressure in the arteries, which occurs near the end of the cardiac cycle when the ventricles are contracting) of 115 mmHg and diastolic pressure (which is minimum pressure in the arteries, which occurs near the beginning of the cardiac cycle when the ventricles are filled with blood) of 75 mmHg (commonly written as 115/75 mmHg), cardiovascular disease (CVD) risk doubles for each increment of 20/10 mmHg.

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