Immunology

The role of monosodium urate crystals in gout

An attack of gout is said to be like your joint catching fire, and someone slamming it with a hammer to put out the flames. Now A*STAR researchers have identified how the build-up of monosodium urate (MSU) crystals in the ...

Immunology

Master detox molecule boosts immune defenses

Scientists at the Luxembourg Institute of Health (LIH) have discovered hitherto unknown molecular mechanism by which the human immune system activates its immune cells. T cells that express a gene known as Gclc effectively ...

Immunology

DNA as a weapon of immune defense

Our innate immune system, made up mainly of phagocytes, protects our body by exterminating bacteria. To do this, it uses two mechanisms. The first kills foreign bodies within the phagocyte itself. The second kills them outside ...

Medical research

Protein NBS1 is crucial for macrophage functional activity

Protein NBS1, which plays a key role in DNA damage repair, is required for macrophage functional activity. This is one of the conclusions of a scientific paper published in the journal Blood by a team of experts from the ...

Genetics

More anti-inflammatory genes mean longer lifespans for mammals

We age in part thanks to "friendly fire" from the immune system—inflammation and chemically active molecules called reactive oxygen species that help fight infection, but also wreak molecular havoc over time, contributing ...

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