Diseases, Conditions, Syndromes

Older patients with Crohn's disease benefit from new medications

Combining medications that suppress the immune system has been successful in treating young patients with Crohn's disease, but some physicians have been reluctant to use this strategy in older patients because of concerns ...

Medical research

New treatment prevents transplant rejection

A new treatment strategy could increase the success rate of stem cell transplants, according to University of Queensland researchers.

Diseases, Conditions, Syndromes

New histoplasmosis risk map

Histoplasmosis is a common lung infection caused by microscopic fungal spores that reside in soil. Most people who inhale the spores don't get sick, but for those with weakened immune systems, the infection can become severe. ...

Immunology

Can we get the immune system to tolerate organ transplants?

Currently, people receiving organ transplants must take drugs to suppress the inflammatory immune response that leads to rejection. Even so, almost all recipients eventually lose their transplant. A new approach, which maintains ...

Immunology

Immune-related adverse events up with checkpoint inhibitors

(HealthDay)—Although patients with pre-existing autoimmune disease who receive checkpoint inhibitors (CPIs) are at risk for exacerbation of their disease, immune-related adverse events (irAEs), or both, events can often ...

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Immunosuppression

Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Deliberately induced immunosuppression is generally done to prevent the body from rejecting an organ transplant, treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as rheumatoid arthritis or Crohn's disease. This is typically done using drugs, but may involve surgery (splenectomy), plasmapharesis, or radiation.

A person who is undergoing immunosuppression, or whose immune system is weak for other reasons (for example, chemotherapy, HIV, and Lupus) is said to be immunocompromised.

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