Surgery

Five-year outcomes for Brigham face transplant recipients

Brigham surgical teams have performed face transplants for people who have suffered from severe facial injuries. The surgery holds the promise of improving physical and mental health for patients who have been severely disfigured ...

Medical research

New treatment prevents transplant rejection

A new treatment strategy could increase the success rate of stem cell transplants, according to University of Queensland researchers.

Immunology

Can we get the immune system to tolerate organ transplants?

Currently, people receiving organ transplants must take drugs to suppress the inflammatory immune response that leads to rejection. Even so, almost all recipients eventually lose their transplant. A new approach, which maintains ...

Diseases, Conditions, Syndromes

New study targets lethal fungal infection

The development of new drugs to fight a common fungal pathogen which kills half a million people globally each year is a step closer thanks to a University of Queensland-led study.

Immunology

Deciphering an embryo-protecting protein

Revelations about a protein expressed in fetal cells could provide novel insights into its function and future immunosuppressive therapies.

Oncology & Cancer

New study supports surgery as treatment for myasthenia gravis

In a global study of myasthenia gravis, an autoimmune disease that causes muscle weakness and fatigue, researchers found that surgical removal of an organ called the thymus reduced patients' weakness, and their need for immunosuppressive ...

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Immunosuppressive drug

Immunosuppressive drugs or immunosuppressive agents are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to:

These drugs are not without side-effects and risks. Because the majority of them act non-selectively, the immune system is less able to resist infections and the spread of malignant cells. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, liver, and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.

Immunosuppressive drugs can be classified into five groups:

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