One promising approach to treating type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections. However, one major ...
Sep 18, 2023
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People who are treated with TNF-α inhibitors for their autoimmune disease such as Crohn's disease or rheumatoid arthritis lose their vaccination protection significantly earlier than average. The mechanism underlying the ...
Sep 6, 2023
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A new paper in Rheumatology Advances in Practice indicates that granulomatosis with polyangiitis, a nasal disease that causes inflammation of the blood vessels and commonly presents with symptoms in sinuses, throat, lungs, ...
Apr 4, 2023
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A new study led by researchers at Harvard Medical School details the step-by-step cascade that allows bacteria to break through the brain's protective layers—the meninges—and cause brain infection, or meningitis, a highly ...
Mar 1, 2023
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Researchers at Vanderbilt University Medical Center have developed a new investigational drug that can block inflammatory signaling in a preclinical model of atopic dermatitis—eczema.
Jan 12, 2023
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A quarter-sized device created at Houston Methodist could drastically alter the course of treatment for type 1 diabetes, a chronic condition that impacts millions of Americans and does not have a cure.
Dec 27, 2022
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The cancer therapy known as CAR-T has revolutionized treatment of some blood cancers since it was introduced in 2017. The therapy uses genetically altered immune cells to home in on cancer cells and destroy them.
Dec 6, 2022
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New research presented this week at ACR Convergence 2022, the American College of Rheumatology's annual meeting, found no clear association between immunosuppressive or anti-fibrotic medications and worsening gastrointestinal ...
Nov 8, 2022
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People with autoimmune or auto-inflammatory rheumatic diseases have an increased risk of infections. This can be due to the underlying disease itself, or may be caused by treatment with immunomodulating or immunosuppressive ...
Oct 28, 2022
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Receiving a medical diagnosis can be difficult. You may only hear parts of the conversation as you start to think about what treatment will be needed and how this will affect your daily life. It can be especially challenging ...
Oct 17, 2022
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Immunosuppressive drugs or immunosuppressive agents are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to:
These drugs are not without side-effects and risks. Because the majority of them act non-selectively, the immune system is less able to resist infections and the spread of malignant cells. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, liver, and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.
Immunosuppressive drugs can be classified into five groups:
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