Alzheimer's disease & dementia

Genome-wide survey examines recessive Alzheimer disease gene

Runs of homozygosity (ROHs, regions of the genome where the copies inherited from parents are identical) may contribute to the etiology (origin) of Alzheimer disease (AD), according to a study in JAMA Neurology by Mahdi Ghani, ...

Genetics

Gene clues point to Cambodia for resistant malaria

Gene analysis of malaria parasites has pinpointed western Cambodia as the hotspot of strains that are dangerously resistant to artesiminin, the frontline drug against the disease, scientists said on Sunday.

Genetics

Golden retrievers help scientists track human disease genes

A team of EU-funded researchers has successfully identified a gene that triggers a skin disorder in dogs - and the findings could have implications for humans who also suffer from the condition. Whether it manifests in golden ...

Inbreeding

Inbreeding is breeding between close relatives, whether plant or animal. If practiced repeatedly, it can lead to exposure of recessive, deleterious traits. This generally leads to a decreased fitness of a population, which is called inbreeding depression. Deleterious alleles causing inbreeding depression can subsequently be removed through culling. This is known as genetic purging.

Livestock breeders often practice inbreeding to "fix" desirable characteristics within a population. However, they must then cull unfit offspring, especially when trying to establish the new and desirable trait in their stock.

In plant breeding, inbred lines are used as stocks for the creation of hybrid lines to make use of the heterosis effect. Inbreeding in plants also occurs naturally in the form of self-pollination.

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