Diabetes

Tiny change has big effects, reverses prediabetes in mice

A small chemical change—shifting the position of two hydrogen atoms—makes the difference between mice that are healthy and mice with insulin resistance and fatty liver, major risk factors for diabetes and heart disease. ...

Health

Doctors need nutrition education, says commentary

Nutrition knowledge is essential for today's physicians, according to a JAMA Internal Medicine commentary published July 1. The commentary—authored by Neal Barnard, MD, president of the Physicians Committee for Responsible ...

Diabetes

Food insecurity leading to type 2 diabetes

A collaborative study by a team of Connecticut researchers shows there is a strong connection between food insecurity and insulin resistance, the underlying problem in type 2 diabetes. Insulin resistance occurs when cells ...

Diabetes

Stem-cell based therapy for type 2 diabetes and obesity

An article published in Experimental Biology and Medicine details a new therapeutic strategy for obesity and type 2 diabetes. The study, led by Dr. Bing Wang, Professor in the Department of General Surgery at Shanghai Ninth ...

Psychology & Psychiatry

Diabetes drug alleviates anxiety in mice

The antidiabetic medication metformin reduces anxiety-like behaviors in male mice by increasing serotonin availability in the brain, according to a study published in JNeurosci. These findings could have implications for ...

Diabetes

Improved diabetes in spite of obesity

Eating too much fat and sugar causes weight gain and reduced health. But why is that, and is there a remedy? In a study published in the journal Cell, Prof. Jens Brüning's research group at the Max Planck Institute for Metabolism ...

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Insulin resistance

Insulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.

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