Medical research

New drug helps combat metabolic syndrome

A new drug developed at Yale reduces a host of abnormalities associated with metabolic syndrome, an obesity-born condition that afflicts one of three adults in the United States, researchers report Oct. 2 in the journal Science ...

Diabetes

Designer type 2 diabetes drug comes with added benefits

A potential new treatment for type 2 diabetes has multiple, positive effects on health and metabolism in mice, reports a study in Nature. The new drug might have potential for treating a variety of disorders in addition to ...

Alzheimer's disease & dementia

New biomarker for dementia improves risk prediction

Identifying individuals who are at risk for developing dementia, including Alzheimer's disease, is critical for the development of new therapies and interventions to slow or reverse cognitive symptoms. But current strategies ...

Medical research

Scientists link 'hunger hormone' to memory in Alzheimer's study

Scientists at The University of Texas at Dallas have found evidence suggesting that resistance to the "hunger hormone" ghrelin in the brain is linked to the cognitive impairments and memory loss associated with Alzheimer's ...

Diabetes

Discovery may point to better treatments for type 1 diabetes

Researchers at Vanderbilt University Medical Center led by an assistant professor of Pediatrics have made a paradigm-shifting discovery that could lead to new treatments, better health and longer life for patients with type ...

Psychology & Psychiatry

Meaningful PTSD symptom decrease may lower type 2 diabetes risk

Research from Saint Louis University finds treatment for Post-Traumatic Stress Disorder (PTSD) that leads to an improvement in symptoms was associated with a 49 percent lower risk of incident type 2 diabetes.

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Insulin resistance

Insulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.

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