Diabetes

Telmisartan reverses insulin resistance in mice

(HealthDay)—Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ (PPAR-δ) gene is present, according to ...

Medical research

Doubling down against diabetes: Turbo-charged gut hormones

A collaboration between scientists in Munich, Germany and Bloomington, USA may have overcome one of the major challenges drug makers have struggled with for years: Delivering powerful nuclear hormones to specific tissues, ...

Medical research

Target for obesity drugs comes into focus

(Medical Xpress)—Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and body weight, interacts with a key receptor in the brain.

Genetics

Genetic variant is linked to obesity and insulin resistance

A large study in people at risk of diabetes has found a direct association between the presence of a small genetic alteration in a hormone receptor and increased body fat and insulin resistance. The results, to be presented ...

Diabetes

Absolute incretin effect reduced in type 2 diabetes

(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) the absolute incretin effect is reduced compared with healthy individuals, but its relative importance is increased, particularly in first-phase insulin secretion, ...

Medical research

New brain target for appetite control identified

Researchers at Columbia University Medical Center (CUMC) have identified a brain receptor that appears to play a central role in regulating appetite. The findings, published today in the online edition of Cell, could lead ...

Overweight & Obesity

Improving obesity-induced insulin sensitivity

In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into ...

Diabetes

Insulin receptor substrate 1 variant linked to GFR

(HealthDay) -- A variant of the human insulin receptor substrate 1 (IRS1) gene, which plays an important role in modulating tissue response to insulin, is significantly associated with glomerular filtration rate (GFR), according ...

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