Immunology

Exercising muscle combats chronic inflammation on its own

Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of ...

Diseases, Conditions, Syndromes

COVID-19 virus helps block host immunity

SARS-CoV-2, the virus that causes COVID-19, blocks the processes of innate immune activation that normally direct the production and/or signaling of type I interferon (IFN-I) by the infected cell and tissues. IFN-I is a key ...

Diseases, Conditions, Syndromes

Scientists identify 'immune cop' that detects SARS-CoV-2

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified the sensor in human lungs that detects SARS-CoV-2 and signals that it's time to mount an antiviral response. The study, published today in Cell ...

Diseases, Conditions, Syndromes

Why are some COVID-19 infected people asymptomatic?

Researchers worldwide have been surprised to see that individuals can be infected with the SARS-CoV-2 virus—the virus that produces COVID-19—without showing symptoms. Since these individuals expose others to infection ...

Diseases, Conditions, Syndromes

Researchers develop new mouse model for SARS-CoV-2

Researchers at Yale University School of Medicine have developed a new mouse model to study SARS-CoV-2 infection and disease and to accelerate testing of novel treatments and vaccines against the novel coronavirus. The study, ...

Diseases, Conditions, Syndromes

Hallmark of severe COVID-19 patients identified

A large team of researchers with members affiliated with a host of institutions in France has identified what they believe is a hallmark of severe COVID-19 patients. In their paper published in the journal Science, the group ...

Diseases, Conditions, Syndromes

Type III interferon in COVID-19: Protective or harmful?

Our immune system makes interferons and other cytokines to help us fight viruses. But in COVID-19, we've learned that they can also contribute to damaging, potentially life-threatening lung inflammation. New work published ...

Diseases, Conditions, Syndromes

Type III interferons: Protective or harmful in COVID-19?

Interferons and other cytokines produced by the immune system are important defenses against viral infections, but as we have seen in COVID-19, they can also contribute to damaging, potentially life-threatening lung inflammation. ...

Immunology

How a fat cell's immune response makes obesity worse

When obesity occurs, a person's own fat cells can set off a complex inflammatory chain reaction that can further disrupt metabolism and weaken immune response—potentially placing people at higher risk of poor outcomes from ...

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