Medical research

Gut epithelium muscles up against infection

To maximize absorption of nutrients from the diet, the intestinal mucous membrane has a large surface area. However, this also makes it vulnerable to attack from aggressive gut microbes. A new study by Uppsala University ...

Immunology

Stopping intestinal bacteria in their tracks

The intestine harbors the greatest number of immune cells in our body. Since the intestine is constantly exposed to various antigens like bacteria and food, appropriate induction of gut immune cells plays a pivotal role in ...

Immunology

Gut cells sound the alarm when parasites invade

To effectively combat an infection, the body first has to sense it's been invaded, then the affected tissue must send out signals to corral resources to fight the intruder. Knowing more about these early stages of pathogen ...

Medical research

Creating an alternative to animal experiments

The human intestine is vital for both digestion and absorbing nutrients as well as drugs. For any type of research that involves intestines, scientists require research models that reflect the physiological situation inside ...

Immunology

Transporter's role in gut barrier linked to intestinal dysfunction

The cotransporter NKCC1 moves sodium, potassium and chloride ions across the cell membrane of many cell types, including intestinal epithelial cells. Two patients with mutations in NKCC1 suffered from severe intestinal dysfunction ...

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