Medical research

Creating an alternative to animal experiments

The human intestine is vital for both digestion and absorbing nutrients as well as drugs. For any type of research that involves intestines, scientists require research models that reflect the physiological situation inside ...

Immunology

Transporter's role in gut barrier linked to intestinal dysfunction

The cotransporter NKCC1 moves sodium, potassium and chloride ions across the cell membrane of many cell types, including intestinal epithelial cells. Two patients with mutations in NKCC1 suffered from severe intestinal dysfunction ...

Medical research

Adult fly intestine could help understand intestinal regeneration

Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research by the ...

Medical research

Artificially engineering the intestine

Short bowel syndrome is a debilitating condition with few treatment options, and these treatments have limited efficacy. The ability to grow artificial intestine is a coveted goal with the potential to profoundly improve ...

Health

Host-microbe interactions in the gut

Although the mutually beneficial relationship between human beings and gut microbes is clear, how we—the host—affect the functions of gut microbial communities remains poorly understood.

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