Medical research

Adult fly intestine could help understand intestinal regeneration

Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research by the ...

Medical research

Artificially engineering the intestine

Short bowel syndrome is a debilitating condition with few treatment options, and these treatments have limited efficacy. The ability to grow artificial intestine is a coveted goal with the potential to profoundly improve ...

Health

Host-microbe interactions in the gut

Although the mutually beneficial relationship between human beings and gut microbes is clear, how we—the host—affect the functions of gut microbial communities remains poorly understood.

Immunology

Intestinal immune cell interactions

Multiple types of immune cells are interspersed among the epithelial cells lining the intestines and are considered to be a first line of defense against pathogens. The survival and interaction of these intraepithelial lymphocytes ...

Immunology

Adhesion protein optimizes border

The epithelial cells that line the intestines build a specialized cell surface—the "brush border"—that processes and absorbs nutrients, and defends against pathogens. The brush border consists of thousands of finger-like ...

Oncology & Cancer

How the immune system protects us against bowel cancer

Researchers at Universitätsmedizin Berlin have discovered a protective mechanism which is used by the body to protect intestinal stem cells from turning cancerous. The body's innate immune system was found to play a pivotal ...

Diseases, Conditions, Syndromes

Going viral: New cells for norovirus production in the lab

An Osaka University-led research team has developed a system for simply and efficiently producing human norovirus. By coaxing human induced pluripotent stem cells (iPSCs) to develop into a type of cell that usually lines ...

Medical research

Does dietary restriction protect against age-related leaky gut?

Flies eating a Spartan diet are protected from leaky gut and the systemic inflammation associated with it as they age. Conversely, flies on a rich Atkins-like diet are more prone to developing intestinal permeability, a condition ...

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