Immunology

A framework for characterizing dendritic cells

Immunological sentinels known as dendritic cells (DCs) help the body eliminate a wide variety of potential threats, from pathogens to cancer—but they are not all created equal. Some DCs are better at fighting bacteria, ...

Medical research

How tumor necrosis factor protects against infection

Tumour necrosis factor (TNF), a messenger substance in the immune system, plays an important role in triggering chronic inflammatory diseases. For this reason, TNF inhibitors are a standard form of treatment for patients ...

Medications

Do it like the immune system: novel antimicrobials

Microbial infections are becoming unbeatable due to progressive mutations that lead to antimicrobial drug resistance. European scientists exploited the characteristics of novel antimicrobial compounds that mimic the dual ...

Diseases, Conditions, Syndromes

How mycobacteria avoid destruction inside human cells

Tuberculosis, or TB, is a dreaded contagious disease of the lungs and other organs. The causative agent, Mycobacterium tuberculosis (or M. tuberculosis), infects roughly a third of the world's population and one-in-ten to ...

Medical research

Immune system quirk could lead to effective tularemia vaccine

Immunologists at the University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh of UPMC and the have found a unique quirk in the way the immune system fends off bacteria called Francisella tularensis, ...