Diseases, Conditions, Syndromes

Computer kidney sheds light on proper hydration

A new computer kidney developed at the University of Waterloo could tell researchers more about the impacts of medicines taken by people who don't drink enough water.

Genetics

Study shines light on architecture of kidney disease

A study of 280,000 U.S. veterans including 56,000 African Americans has identified in greater detail than ever before the "genetic architecture" of kidney function and chronic kidney disease (CKD), according to researchers ...

Diseases, Conditions, Syndromes

Living kidney donors face higher risk of hypertension

Compared with non-donors, living kidney donors face a higher risk of developing hypertension, which may have negative effects on their kidney function. The findings, which appear in an upcoming issue of CJASN, indicate the ...

Cardiology

CV risk lower with metformin in T2DM and reduced kidney function

(HealthDay)—Treatment with metformin versus sulfonylureas is associated with a reduced risk for major adverse cardiovascular events (MACE) among patients with type 2 diabetes and reduced kidney function, according to a ...

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Renal function

Renal function, in nephrology, is an indication of the state of the kidney and its role in renal physiology. Glomerular filtration rate (GFR) describes the flow rate of filtered fluid through the kidney. Creatinine clearance rate (CCr) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR. Both GFR and CCr may be accurately calculated by comparative measurements of substances in the blood and urine, or estimated by formulas using just a blood test result (eGFR and eCCr).

The results of these tests are important in assessing the excretory function of the kidneys. For example, grading of chronic renal insufficiency and dosage of drugs that are primarily excreted via urine are based on GFR (or creatinine clearance).

It is commonly believed to be the amount of liquid filtered out of the blood that gets processed by the kidneys. Physiologically, these quantities (volumetric blood flow and mass removal) are only related loosely.

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