Diseases, Conditions, Syndromes

iPSC-derived kidney organoids to model a lifelong renal disease

Researchers have generated induced pluripotent stem cell (iPSC)-derived kidney organoids to model Alport syndrome caused by a mutation in the COL4A5 gene and have demonstrated the utility of a chemical chaperone to rescue ...

Medications

ICU antibiotics may be safe for kidneys, says clinical trial

Two "big gun" antibiotics thought to cause kidney failure in ICU patients with a severe bacterial infection, especially when combined with another antibiotic, may be safer for the kidneys than previously reported, following ...

Medical research

Zooming in on rare bone cells that drive osteoporosis

Mayo Clinic researchers have developed a new high-resolution, analytical technique to identify the rare senescent bone cells that are known to drive osteoporosis. Senescent cells are malfunctioning cells that build up as ...

Genetics

Women with gene mutation give new insight into blood clot risk

New research from Queen Mary University of London, published in iScience, shows an increased risk of blood clots in women who have any combination of a particular gene mutation, estrogen use, or common medical conditions—specifically: ...

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