Immunology

Researchers discover way to prime cancer tumors for immunotherapy

A cancer tumor's ability to mutate allows it to escape from chemotherapy and other attempts to kill it. So, encouraging mutations would not be a logical path for cancer researchers. Yet a Mayo Clinic team and their collaborators ...

Oncology & Cancer

Clues to improve cancer immunotherapy revealed

Cancer immunotherapy drugs trigger the body's immune system to attack tumors and have revolutionized the treatment of certain cancers, such as lymphoma, lung cancer and melanoma. Yet, while some patients respond well to the ...

Immunology

Creatine powers T cells' fight against cancer

Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer, according ...

Immunology

Gut immunity more developed before birth than previously thought

Most biology textbooks explain that the fetal immune system is largely undeveloped and that it learns after being exposed to the world at birth. New research from the University of Pittsburgh School of Medicine and UPMC Children's ...

Diseases, Conditions, Syndromes

People's initial immune response to dengue fever analyzed

Researchers have come one step closer to understanding how the immune system responds to acute dengue fever, a disease that has affected hundreds of thousands of people in Southeast Asia this summer alone. In a study published ...

Medications

PET imaging shows if PD-1 cancer immunotherapy is working

PD-1 is a protein on our T cells that normally keeps these immune cells from running amok. A growing number of cancer drugs are designed to inhibit PD-1, enabling patients' T-cells to attack and kill cancerous cells. PD-1 ...

Oncology & Cancer

Genome screen uncovers new targets for cancer immunotherapy

Immunotherapy has revolutionized the treatment of cancer in the last decade, yet many tumors do not respond to these new therapies. A new genome-wide screen of 20,000 human genes in T cells have turned up several new candidates ...

Medical research

Killer cells the key to potentially life‑saving cancer vaccines

"I'll be honest, when I first started working on this I didn't fully accept it." That's Dr. Andrew Makrigiannis, head of the Department of Microbiology & Immunology, discussing his groundbreaking research on natural killer ...

Oncology & Cancer

Making cancer stem cells visible to the immune system

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal Nature, scientists from Basel, Tübingen ...

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