Medical research

Could an antibody drug help you shed pounds?

An experimental antibody drug that targets one of the body's key metabolism regulators may help obese people lose weight—at least briefly.

Medical research

New drug helps combat metabolic syndrome

A new drug developed at Yale reduces a host of abnormalities associated with metabolic syndrome, an obesity-born condition that afflicts one of three adults in the United States, researchers report Oct. 2 in the journal Science ...

Neuroscience

High LDL linked to early-onset Alzheimer's

Researchers with the Atlanta Veterans Affairs Medical Center and Emory University have found a link between high LDL cholesterol levels and early-onset Alzheimer's disease. The results could help doctors understand how the ...

Medications

Bladder drug linked to atherosclerosis in mice

A drug used in the treatment of overactive bladder can accelerate atherosclerosis in mice, researchers at Karolinska Institutet in Sweden report in a study published in the Proceedings of the National Academy of Sciences ...

Medical research

Study finds key protein that binds to LDL cholesterol

A Yale-led research team identified a protein that plays an important role in the buildup of LDL cholesterol in blood vessels. The finding could lead to an additional strategy to block LDL accumulation, which could help prevent ...

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Low-density lipoprotein

Low-density lipoprotein (LDL) is a type of lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues. LDL is one of the five major groups of lipoproteins; these groups include chylomicrons, very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein, and high-density lipoprotein (HDL), although some alternative organizational schemes have been proposed. Like all lipoproteins, LDL enables fats and cholesterol to move within the water-based solution of the blood stream. LDL also regulates cholesterol synthesis at these sites. It is used medically as part of a cholesterol blood test, and since high levels of LDL cholesterol can signal medical problems like cardiovascular disease, it is sometimes called "bad cholesterol," (as opposed to HDL, which is frequently referred to as "good cholesterol" or "healthy cholesterol").

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