Diseases, Conditions, Syndromes

Discovery suggests new route to fight infection, disease

New research reveals how a single protein interferes with the immune system when exposed to the bacterium that causes Legionnaires' disease, findings that could have broad implications for development of medicines to fight ...

Diseases, Conditions, Syndromes

Home and hospital health care could be in 'hot water'

Hospitals and homes are havens for germs and disease—but a well-regulated hot water system can prevent the spread of waterborne pathogens, including an emerging infectious disease problem from "superbugs" which can be resistant ...

Diseases, Conditions, Syndromes

Discovery of a new therapeutic target to fight against Legionella

Science is tightening the net around Legionella. A study conducted by the Basque Center for Cooperative Research in Biosciences, CIC bioGUNE, in collaboration with the National Institutes of Health (NIH, USA) and the Barcelona ...

Diseases, Conditions, Syndromes

Water systems study finds Legionella in 41% of samples

A new study of domestic and hospital drinking water systems found Legionella in 41% of samples—with Flinders University researchers making a key connection between the pathogen's co-existence with a "host" microorganism ...

Diseases, Conditions, Syndromes

Garden hose a breeding ground for Legionnaires' disease

It is synonymous with an Aussie summer but the humble backyard hose could be a bacterial breeding ground, providing the ideal conditions for the organisms that cause Legionnaires' disease to flourish, UNSW research has revealed.

Diseases, Conditions, Syndromes

Legionnaires' disease bacteria found at hotel; one guest died

The bacteria that causes Legionnaires' disease was found in rooms of a hotel in a popular Missouri tourist town associated with Mark Twain, and health officials said Tuesday that one of three people who contracted the disease ...

Diseases, Conditions, Syndromes

Hong Kong government offices hit by deadly bug

The bacteria that cause Legionnaires' disease have been found at several sites in the new Hong Kong government complex after one minister fell ill, in a major embarrassment for the authorities.

Diseases, Conditions, Syndromes

Legionnaires' disease outbreak hits Long Island, N.Y.

(HealthDay)—Health officials say they are trying to track down the source of 10 reported cases of Legionnaires' disease within a one-mile radius in a Long Island, N.Y., neighborhood.

Diseases, Conditions, Syndromes

Nevada officials: Luxor guests had Legionnaires'

(AP) -- Health officials in Las Vegas said Monday that the bacteria that causes Legionnaires' disease was found in water samples at the Luxor hotel-casino this month after a guest died of the form of pneumonia.

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Legionella

Legionella is a pathogenic Gram negative bacterium, including species that cause legionellosis or Legionnaires' disease, most notably L. pneumophila. It may be readily visualized with a silver stain.

Legionella is common in many environments, with at least 50 species and 70 serogroups identified. The side-chains of the cell wall carry the bases responsible for the somatic antigen specificity of these organisms. The chemical composition of these side chains both with respect to components as well as arrangement of the different sugars determines the nature of the somatic or O antigen determinants, which are essential means of serologically classifying many Gram-negative bacteria.

Legionella acquired its name after a July, 1976 outbreak of a then-unknown "mystery disease" sickened 221 persons, causing 34 deaths. The outbreak was first noticed among people attending a convention of the American Legion - an association of U.S. military veterans. The convention in question occurred in Philadelphia during the U.S. Bicentennial year. This epidemic among U.S. war veterans, occurring in the same city as – and within days of the 200th anniversary of – the signing of the Declaration of Independence, was widely publicized and caused great concern in the United States. On January 18, 1977 the causative agent was identified as a previously unknown bacterium, subsequently named Legionella. See Legionnaires' Disease for full details.

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