The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia
A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease.
A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease.
Researchers at Lund University Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome (MDS) patients. In a study ...
Mar 21, 2023
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While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation that could also drive resistance to targeted ...
Mar 1, 2022
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Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML)—called NPM1—that could help predict survival and improve ...
Feb 16, 2021
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Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. However, the side effects of therapies are often severe. A group of researchers led by the University of Zurich have now shown ...
May 8, 2020
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St. Jude Children's Research Hospital researchers have made a discovery that expands the list of genes to include when screening individuals for possible increased susceptibility to childhood leukemia. The finding is reported ...
Apr 19, 2018
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Vitamin C may "tell" faulty stem cells in the bone marrow to mature and die normally, instead of multiplying to cause blood cancers. This is the finding of a study led by researchers from Perlmutter Cancer Center at NYU Langone ...
Aug 17, 2017
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A protein-sugar molecule, CD99, occurs more frequently than normal on stem cells responsible for blood cancers, including acute myeloid leukemia (AML) and the related myelodysplastic syndromes (MDS).
Jan 25, 2017
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In preliminary experiments with mice and lab-grown cells, Johns Hopkins Kimmel Cancer Center scientists have found that a protein-signaling process accelerates the work of the gene most frequently mutated in a common form ...
Jun 10, 2015
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Researchers have identified a genetic/molecular network that fuels a high-risk and aggressive form of Acute Myeloid Leukemia (AML) and its precursor disease Myelodysplastic Syndrome (MDS) – providing a possible therapeutic ...
Sep 4, 2014
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