Diseases, Conditions, Syndromes

New web server helps identify COVID-19 drug candidates

Rice University researchers have introduced an online portal to help researchers screen COVID-19 drug candidates that might attack specific proteins of the SARS-CoV-2 virus.

Oncology & Cancer

Switching off the 'survival protein' for cancer cells

Proteins control almost all vital processes in our cells. If they do not function correctly, if there is too much or too little of them, this can lead to the development of a variety of diseases including cancer. The associated ...

Medical research

Cow's milk protein beta-lactoglobulin prevents allergies

Numerous studies have shown that growing up on a farm and drinking natural, unprocessed cow's milk in early childhood protects against the development of immunoglobulins E (IgE), which are responsible for allergy symptoms. ...

Parkinson's & Movement disorders

Drug homing method helps rethink Parkinson's

The brain is the body's most complex organ, and consequently the least understood. In fact, researchers like Michael Tadross, MD, PhD, wonder if the current research methods employed by neuroscientists are telling us as much ...

Oncology & Cancer

Extracellular vesicles could be personalized drug delivery vehicles

Creating enough nanovesicles to inexpensively serve as a drug delivery system may be as simple as putting the cells through a sieve, according to an international team of researchers who used mouse autologous—their own—immune ...

Oncology & Cancer

Double targeting ligands to identify and treat prostate cancer

Researchers have demonstrated a new, effective way to precisely identify and localize prostate cancer tumors while protecting healthy tissue and reducing side effects. The new approach utilizes a single molecule designed ...

Medications

Cyclic opioid peptides

Peptide based drug candidates are being discovered at an increasingly rapid pace as therapeutics for many diseases and pain management. . For decades the opioid receptors have been an attractive therapeutic target for pain ...

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Ligand

In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from covalent to ionic. Furthermore, the metal-ligand bond order can range from one to three. Ligands are viewed as Lewis bases, although rare cases are known involving Lewis acidic "ligands."

Metal and metalloids are bound to ligands in virtually all circumstances, although gaseous "naked" metal ions can be generated in high vacuum. Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry, homogeneous catalysis, and environmental chemistry.

Ligands are classified in many ways: their charge, their size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity). The size of a ligand is indicated by its cone angle.

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