Oncology & Cancer
Metastatic 'switch' could lead to cancer therapies
(Medical Xpress)—What kills cancer patients often isn't the primary tumor; it's when the tumor metastasizes—or spreads the cancer to other areas of the body.
Sep 11, 2012
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News tagged with ligand
Oncology & Cancer
Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved
Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells.
May 30, 2012
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Health
Post-run ice baths not beneficial for strength, soreness, researchers say
Dunking in a tub of ice water after exercise – a surprisingly popular post-workout regimen used by athletes to reduce inflammation and speed recovery – is time consuming and bone-achingly painful. New research from the ...
Aug 19, 2013
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Oncology & Cancer
Scientists find new marker that predicts early recurrence of breast cancer
A multi-institutional team led by scientists from the Medical College of Wisconsin (MCW) Cancer Center has discovered PD-L2 as a therapy-relevant marker to identify patients with estrogen receptor-positive breast cancer who ...
Jan 25, 2023
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Neuroscience
Scientists elucidate how chemogenetic technology highjacks neuronal activity
Understanding of how neuronal activity modulates brain function is a key first step towards creating more effective drugs to treat a variety of neuropsychiatric illnesses, including depression, anxiety, schizophrenia, substance ...
Nov 30, 2022
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Oncology & Cancer
Double targeting ligands to identify and treat prostate cancer
Researchers have demonstrated a new, effective way to precisely identify and localize prostate cancer tumors while protecting healthy tissue and reducing side effects. The new approach utilizes a single molecule designed ...
Sep 7, 2017
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Genetics
Chromosome 12 mutation linked to familial diarrhea
(HealthDay) -- An activating mutation in GUCY2C, encoding guanylate cyclase C (GC-C), is thought to cause a novel familial diarrhea syndrome seen in a Norwegian family, according to a study published online March 21 in the ...
Mar 22, 2012
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Alzheimer's disease & dementia
Drugs found to both prevent and treat Alzheimer's disease in mice
Researchers at USC have found that a class of pharmaceuticals can both prevent and treat Alzheimer's Disease in mice.
May 21, 2013
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Oncology & Cancer
Engineered antibody demonstrated safety, efficacy in wide range of advanced tumors
(Medical Xpress)—The engineered antibody MPDL3280A, which targets a protein called programmed death-ligand 1 (PD-L1), was safe and effective for several cancers, according to phase I study results presented at the AACR ...
Apr 10, 2013
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Medications
Cyclic opioid peptides
Peptide based drug candidates are being discovered at an increasingly rapid pace as therapeutics for many diseases and pain management. . For decades the opioid receptors have been an attractive therapeutic target for pain ...
Jul 13, 2016
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