Oncology & Cancer

Lexatumumab tolerated for pediatric solid tumors

(HealthDay)—Lexatumumab, an agonistic, full human monoclonal antibody against tumor necrosis factor-related apoptosis-inducing ligand receptor 2, is well tolerated and may lessen certain clinical symptoms in some pediatric ...

Immunology

Jump-starting cheaper cancer vaccines

Dendritic cells (DCs)—workhorses of the immune system—derived from human embryonic stem cells (hESCs) may provide an economical way of generating off-the-shelf therapeutic vaccines against cancers, according to research ...

Oncology & Cancer

Denosumab reduces burden of giant-cell tumor of the bone

Treatment with denosumab, a drug targeted against a protein that helps promote bone destruction, decreased the number of tumor giant cells in patients with giant-cell tumor of the bone, and increased new bone formation, according ...

Medical research

Mechanism ID'd for benefit of stem cells in autoimmunity

(HealthDay) -- Bone marrow mesenchymal stem cells (BMMSCs) activate a mechanism involving coupling of FAS/FAS ligand to induce T cell apoptosis and immune tolerance, according to an experimental study published online April ...

Immunology

Immune cells, 'macrophages' become activated by body temperature

Macrophages playing an important role in the immune system eat and fight against pathogens and foreign substances in the very beginning of infection. In this condition, macrophages produce reactive oxygen species for sterilization. ...

Oncology & Cancer

A silver bullet to beat cancer?

The internet is awash with stories of how silver can be used to treat cancer. Now, lab tests have shown that it is as effective as the leading chemotherapy drug - and may have fewer side-effects.

Oncology & Cancer

A gene that protects against colorectal cancers

The research team in France has developed an animal model carrying a mutation of the DCC gene. Mice carrying the mutation develop tumours, because this gene can no longer induce the death of the cancer cells. This discovery ...

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