Professor Yi Sun's team at the Zhejiang University report a functional compensatory effect between the Ube2m-Rbx1 and Ube2f-Sag axes of the neddylation–Cullin-RING ligases (CRLs) system in Treg cells, using conditional ...
Dec 22, 2023
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A gene regulating the F-Box and WD Repeat Domain Containing 7 (FBXW7) protein is frequently mutated or deleted in various types of human cancer, including gynecological cancers. Such FBXW7 mutations have been associated with ...
May 18, 2023
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A recent study published in Oncogene and led by Dr. Sun Yu's group at Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences revealed the roles and functional mechanisms of senescence-associated ...
Oct 25, 2022
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More-effective therapies are greatly needed for children with the high-risk blood cancer T-cell acute lymphoblastic leukemia (T-ALL). St. Jude Children's Research Hospital scientists have leveraged the latest chemical technology ...
Aug 24, 2022
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A new study led by scientists at Sanford Burnham Prebys has shown that the protein RNF5 plays an unusual role in acute myeloid leukemia (AML). Unlike its expected role, marking aberrant proteins for destruction, RNF5 binds ...
Sep 13, 2021
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Researchers report that infantile spasms, a rare but serious seizure disorder in babies, appear to be the result of a molecular pathway gone awry. In their study of a mouse model of the disorder, the researchers discovered ...
Aug 3, 2021
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Scientists at The University of Manchester have developed a more efficient method to produce medicines that are in development for the treatment of COVID-19, cancer and other diseases that affect many of the world's population.
May 20, 2021
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Over many decades now, traditional drug discovery methods have steadily improved at keeping diseases at bay and cancer in remission. And for the most part, it's worked well.
Feb 25, 2021
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In the last several years, excitement has surged for a promising class of drugs that work not by inhibiting the action of a molecular target, as most conventional drugs do, but instead by harnessing the cell's recycling system ...
Jun 4, 2020
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The RAF protein could be a therapeutical target to treat tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine ...
Feb 20, 2020
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