Cancer

Reprograming T cells to attack solid tumors

An attractive approach to liver cancer treatment is to bolster the body's own immune defenses. Now an international team involving A*STAR researchers has genetically engineered human T cells to endow them with both specificity ...

Medical research

Blood holds key to liver regeneration

The liver is the only organ in the body that can regenerate. But some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process ...

Cancer

Cancer most frequently spreads to the liver; here's why

When cancer spreads to another organ, it most commonly moves to the liver, and now researchers at the Abramson Cancer Center of the University of Pennsylvania say they know why. A new study, published today in Nature, shows ...

Medical research

Metabolic remodeling during regeneration

A healthy liver has a significant capacity to regenerate after injury or disease, but little was known about the accompanying detailed changes in cell metabolism. An international research team, that includes scientists from ...

Genetics

Tissue model reveals how RNA will act on the liver

Novel therapies based on a process known as RNA interference (RNAi) hold great promise for treating a variety of diseases by blocking specific genes in a patient's cells. Many of the earliest RNAi treatments have focused ...

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Hepatocyte

Hepatocytes make up 70-80% of the cytoplasmic mass of the liver. These cells are involved in protein synthesis, protein storage and transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, and detoxification, modification and excretion of exogenous and endogenous substances. The hepatocyte also initiates the formation and secretion of bile.

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