A team of Duke researchers has discovered that cells lining the gut of zebrafish—and probably humans too—have a remarkable defense mechanism when faced with certain kinds of toxins: they hit the eject button.
Aug 5, 2019
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Innovative carbon beads, invented by researchers at UCL, reduce bad bacteria and inflammation in animal models, which are linked to liver cirrhosis and other serious health issues.
Apr 14, 2024
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A drug screening system that models cancers using lab-grown tissues called organoids has helped uncover a promising target for future pancreatic cancer treatments, according to a new study from researchers at Weill Cornell ...
Dec 27, 2023
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A team of researchers has uncovered a previously unknown compensatory mechanism found in liver disease. If Kupffer cells (KCs), a specific kind of immune cells found in the liver, become impaired by tissue scarring, immune ...
Sep 28, 2023
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A severe form of fatty liver disease called nonalcoholic steatohepatitis (NASH) is the leading cause of liver transplantation, but there are few treatment options and currently no medications. In a new study, Yale researchers ...
Sep 27, 2023
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UCLA-led research describes the role that a protein called CEACAM1 plays in protecting the liver from injury during the transplantation process, potentially improving transplant outcomes. But the features that regulate this ...
Aug 2, 2023
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The RNF41 protein could be a new therapeutic target in the fight against two chronic liver diseases: cirrhosis and liver inflammation. This is the conclusion of a study published in the journal Science Translational Medicine ...
Jul 28, 2023
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Duke Health researchers have identified the cause of an inherited metabolic disease common among people with Lumbee and other Native American heritage, overturning decades of settled science and pointing to new, more effective ...
Apr 19, 2023
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A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates—bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing ...
Apr 10, 2023
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Scientists have identified an autoinflammatory disease caused by mutations in the LYN gene, an important regulator of immune responses in health and disease. Named Lyn kinase-associated vasculopathy and liver fibrosis (LAVLI), ...
Mar 28, 2023
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Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the organ. Other chemical agents such as those used in laboratories and industries, natural chemicals (e.g. microcystins) and herbal remedies can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins.
More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Chemicals often cause subclinical injury to liver which manifests only as abnormal liver enzyme tests. Drug induced liver injury is responsible for 5% of all hospital admissions and 50% of all acute liver failures.
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