Genetics

CRISPR 'minigene' approach stops genetic liver disease in mice

A new CRISPR gene-editing technique prevented a genetic liver disease known to be driven by hundreds of different mutations and improved clinical symptoms in mice, Penn Medicine researchers reported in new proof-of-concept ...

Oncology & Cancer

Cancers don't sleep: The Myc oncogene can disrupt circadian rhythm

The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells. Postdoctoral fellow Brian Altman, PhD, and graduate student Annie Hsieh, MD, both from the in the lab of Chi Van Dang, MD, PhD, director of the Abramson ...

Medications

Your lifestyle can determine how well your medicine will work

By examining liver samples from 116 deceased persons with severe mental disorders, researchers have demonstrated that smoking, obesity and alcohol use can be decisive in determining how medicine will work for an individual ...

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