Medical research

Lymphoma's different route revealed

Creating new blood vessels, a process called angiogenesis, for tumors in lymph nodes is different than for tumors in other parts of the body, such as the colon or lung, a team from the Max Delbrueck Center for Molecular Medicine ...

Oncology & Cancer

Low muscle mass, density linked to shorter survival in lymphoma

(HealthDay)—The combination of low muscle mass (LMM) and low muscle density (LMD) is associated with shorter survival in patients with diffuse large B-cell lymphoma (DLBCL), according to a study published online March 13 ...

Oncology & Cancer

Cancer survival rates improve for young adults

A new study in the Journal of the National Cancer Institute, published by Oxford University Press, finds improvements in five-year survival rates for all cancers in young adults. For some cancers, however, there has been ...

Oncology & Cancer

Researchers show that DNA topological problems may cause lymphoma

Researchers from the Spanish National Cancer Research Centre (CNIO), Madrid, and the Andalusian Molecular Biology and Regenerative Medicine Centre (Cabimer), Seville, published a paper in Nature Communications that shows ...

Oncology & Cancer

Childhood cancer rates increase with no change in sight

The overall incidence rate of childhood cancer in Australia increased by 1.2% per year between 2005 and 2015, and is expected to rise a further 7% over the next 20 years, according to the authors of research published in ...

Oncology & Cancer

Young cancer survivors at higher risk for hospitalization

(HealthDay)—Adolescent and young adult (AYA) cancer survivors (aged 15 to 39 years) have an increased risk for inpatient hospitalization, according to a study published online Jan. 20 in Cancer Epidemiology, Biomarkers ...

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Lymphoma

Lymphoma is a type of cancer that originates in lymphocytes of the immune system. They often originate in lymph nodes, presenting as an enlargement of the node (a tumor). Lymphomas are closely related to lymphoid leukemias, which also originate in lymphocytes but typically involve only circulating blood and the bone marrow (where blood cells are generated in a process termed haematopoesis) and do not usually form static tumours. There are many types of lymphomas, and in turn, lymphomas are a part of the broad group of diseases called hematological neoplasms.

Thomas Hodgkin published in 1832 the first description of lymphoma, specifically of the form named after him, Hodgkin's lymphoma. Since then many other forms of lymphoma have been described, grouped under several proposed classifications. The 1982 Working formulation classification became very popular. It introduced the category non-Hodgkin lymphoma (NHL), itself divided into 16 different diseases. However, since these different lymphomas have little in common with each other, the NHL label is of limited usefulness for doctors or patients and is slowly being abandoned. The latest classification by the WHO (2001) lists 43 different forms of lymphoma divided in four broad groups.

Some forms of lymphoma are indolent (e.g. small lymphocytic lymphoma), compatible with a long life even without treatment, whereas other forms are aggressive (e.g. Burkitt's lymphoma), causing rapid deterioration and death. The prognosis therefore depends on the correct classification of the disease, established by a pathologist after examination of a biopsy.

Although older classifications referred to histiocytic lymphomas, these are recognized in newer classifications as of B, T or NK cell lineage. True histiocytic malignancies are rare and are classified as sarcomas.

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