Tumor suppressor genes protect cells from malignant transformation. If they are turned off as a result of chemical modifications in DNA, called epigenetic labels, this contributes to the development of cancer. As opposed ...
Jun 12, 2017
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Metabolism was lost in the shadows of cancer research for decades but has recently been reclaiming some of the spotlight. Now, Mina Bissell, Distinguished Scientist with Berkeley Lab's Life Sciences Division and a leading ...
Dec 18, 2013
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Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive – ...
Jan 17, 2013
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(Medical Xpress)—UC Davis investigators have found new evidence that a promising type of stem cell now being considered for a variety of disease therapies is very similar to the type of cells that give rise to cancer. The ...
Sep 28, 2012
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Benzo[a]pyrene is a potent carcinogen and mutagen present in cigarette smoke, automotive exhaust, burnt wood fumes, barbecued and smoked meat etc.
Oct 24, 2017
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Neurofibromatosis type 1 (NF1)—an autosomal dominant disorder affecting approximately one in every 3,500 people—results in dysfunctional neurofibromin, a protein expressed throughout the body and involved in the RAS signaling ...
Jun 12, 2017
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(Medical Xpress)—Brain tumors known as low-grade gliomas can be treated with surgery, sometimes in combination with chemotherapy and/or radiation therapy, with some patients living for decades after treatment. But because ...
Dec 18, 2013
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Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have developed a small molecule that inhibits STAT3, a protein that causes cancer. This development could impact the treatment of several ...
Mar 26, 2013
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A hormone-like substance produced by the body to promote inflammation can cause an aggressive form of leukemia when present at high levels, according to a new study by researchers at the Ohio State University Comprehensive ...
Nov 12, 2012
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Canadian and Italian stem cell researchers have discovered a new "master control gene" for human blood stem cells and found that manipulating its levels could potentially create a way to expand these cells for clinical use.
Nov 8, 2012
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