Genetics

When mad AIOLOS drags IKAROS down: A novel pathogenic mechanism

Primary immunodeficiencies, such as severe combined immunodeficiency disease (SCID), occur when the immune system does not work properly, leading to increased susceptibility to various infections, autoimmunity, and cancers. ...

Oncology & Cancer

Paving the way for cancer treatments with fewer side effects

In recent years, immunotherapy has revolutionized the field of cancer treatment. However, inflammatory reactions in healthy tissues frequently trigger side effects that can be serious and lead to the permanent discontinuation ...

Sports medicine & Kinesiology

Exoskeleton reduces amount of work required to walk

A team of researchers at Queen's University in Canada has developed an exoskeleton that reduces the metabolic cost of walking. In their paper published in the journal Science, the group describes their system and how it works. ...

Diseases, Conditions, Syndromes

How hepatitis C virus evades the immune system

Hepatitis C virus (HCV) may cause chronic infection to the liver, which can result in irreversible liver damage and liver cancer. How HCV manages to evade the immune system to infect the host chronically is not entirely understood. ...

Medical research

How bone marrow regenerates after chemotherapy

Chemotherapy has a damaging effect on hematopoietic stem and progenitor cells (HSPCs) in bone marrow. However, once chemotherapy ends, HSPCs regenerate, a process that has remained unknown—until now. In a new study, researchers ...

Oncology & Cancer

Why some melanoma patients do not respond to immunotherapy

By harnessing the immune system against cancer, immunotherapies have revolutionized the way some types of cancer are treated. But most patients—across cancer types—do not respond, and in most cases, scientists are at ...

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