Inflammatory disorders

'Super melanin' heals skin injuries from sunburn, chemical burns

Imagine a skin cream that heals damage occurring throughout the day when your skin is exposed to sunlight or environmental toxins. That's the potential of a synthetic, biomimetic melanin developed by scientists at Northwestern ...

Oncology & Cancer

Melanoma misconception: Dark skin tones at risk, too

The myth that people with dark skin are immune to melanoma, a type of skin cancer, has persisted for many years. It's a dangerous misconception that has caused some people not to be diligent about protecting themselves against ...

Medical research

Nitisinone increases melanin in people with albinism

A small pilot clinical study at the National Eye Institute (NEI) suggests that the drug nitisinone increases melanin production in some people with oculocutaneous albinism type 1B (OCA-1B), a rare genetic disease that causes ...

Cardiology

Novel technique accurately assesses cardiovascular risks

A new noninvasive technique for imaging the carotid artery offers advantages over other imaging methods and could provide an earlier, more accurate assessment of cardiovascular disease risk, according to a study published ...

Medical research

Mouse and human skin cells produce melanin on a 48-hour cycle

Researchers have discovered that mouse skin and skin cells from humans produce pigmentation in response to sunlight on a 48-hour cycle. They observed that exposing skin to ultraviolet light every 2 days yielded darker pigmentation ...

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Melanin

Melanin i/ˈmɛlənɪn/ (Greek: μέλας, black) is a pigment that is ubiquitous in nature, being found in most organisms (spiders are one of the few groups in which it has not been detected). In animals melanin pigments are derivatives of the amino acid tyrosine. The most common form of biological melanin is eumelanin, a brown-black polymer of dihydroxyindole carboxylic acids, and their reduced forms. All melanins can be considered as derivatives of polyacetylene, since they rely on a polyconiugate structure. Another common form of melanin is pheomelanin, a red-brown polymer of benzothiazine units largely responsible for red hair and freckles. The presence of melanin in the archaea and bacteria kingdoms is an issue of ongoing debate among researchers in the field.

The increased production of melanin in human skin is called melanogenesis. Production of melanin is stimulated by DNA damage induced by UVB-radiation, and it leads to a delayed development of a tan. This melanogenesis-based tan takes more time to develop, but it is long-lasting.

The photochemical properties of melanin make it an excellent photoprotectant. It absorbs harmful UV-radiation (ultraviolet) and transforms the energy into harmless heat through a process called "ultrafast internal conversion". This property enables melanin to dissipate more than 99.9% of the absorbed UV radiation as heat (see photoprotection). This prevents the indirect DNA damage that is responsible for the formation of malignant melanoma and other skin cancers.

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