Methotrexate reduces pain in hand osteoarthritis with synovitis

For patients with hand osteoarthritis and synovitis, methotrexate has a potentially clinically meaningful effect on reducing pain, with no increase in adverse events, according to a study published online Oct. 12 in The Lancet.


Hair regrowth seen in alopecia with methotrexate + prednisone

For patients with recalcitrant alopecia areata totalis or universalis, methotrexate combined with prednisone yields complete hair regrowth in about 31 percent of patients, according to a study published online March 8 in ...

Oncology & Cancer

Preventing 'chemo brain' with antioxidants targeting the spinal fluid

Up to three quarters of patients receiving cancer chemotherapy suffer from "chemo brain"—a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, ...

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Methotrexate (rINN) ( /mɛθɵˈtrɛkseɪt/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was developed by Yellapragada Subbarao.

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