Oncology & Cancer

Molecular mechanisms reveal how to make the most of methotrexate

St. Jude Children's Research Hospital scientists have identified factors that influence how children with acute lymphoblastic leukemia (ALL) respond to methotrexate. High-dose methotrexate is a part of modern curative therapy ...

Inflammatory disorders

Biologics tied to greater reduction in pediatric psoriasis

(HealthDay)—Biologics seem to be associated with greater reduction in psoriasis severity scores and higher drug survival rates than methotrexate in pediatric patients treated in a real-world setting, according to a study ...

Diseases, Conditions, Syndromes

Study: Some biologic treatments for psoriasis may be safer for patients

A common chronic skin condition affecting 125 million people worldwide, psoriasis is an autoimmune disease, a class of disorders in which the immune system attacks the body's own healthy cells. In recent years, new medications—known ...

Diseases, Conditions, Syndromes

Methotrexate well tolerated, effective for psoriasis in Chinese

(HealthDay)—Methotrexate is well tolerated and effective for psoriasis in a Chinese population and is more effective for those without psoriatic arthritis, according to a study published online Jan. 30 in JAMA Dermatology.

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Methotrexate

Methotrexate (rINN) ( /mɛθɵˈtrɛkseɪt/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was developed by Yellapragada Subbarao.

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