Diseases, Conditions, Syndromes

Study: Some biologic treatments for psoriasis may be safer for patients

A common chronic skin condition affecting 125 million people worldwide, psoriasis is an autoimmune disease, a class of disorders in which the immune system attacks the body's own healthy cells. In recent years, new medications—known ...

Diseases, Conditions, Syndromes

Methotrexate well tolerated, effective for psoriasis in Chinese

(HealthDay)—Methotrexate is well tolerated and effective for psoriasis in a Chinese population and is more effective for those without psoriatic arthritis, according to a study published online Jan. 30 in JAMA Dermatology.

Cancer

Scientists sharpen the edges of cancer chemotherapy with CRISPR

Tackling unsolved problems is a cornerstone of scientific research, propelled by the power and promise of new technologies. Indeed, one of the shiniest tools in the biomedical toolkit these days is the genome editing system ...

Diseases, Conditions, Syndromes

Methotrexate, azathioprine seem safe long-term for dermatitis

(HealthDay)—Methotrexate and azathioprine appear to be effective and safe as maintenance treatments in moderate-to-severe atopic dermatitis for up to five years, according to research published online Dec. 13 in the British ...

Diseases, Conditions, Syndromes

Noninvasive test for NASH, fibrosis in patients with psoriasis

(HealthDay)—For patients with psoriasis receiving long-term methotrexate sodium therapy, a noninvasive test for nonalcoholic steatohepatitis (NASH) and hepatic fibrosis (NASH FibroSure) can be used to monitor development ...

Arthritis & Rheumatism

New oral treatment option for rheumatoid arthritis

Patients suffering from rheumatoid arthritis are treated for around six months with the standard anti-rheumatic agent methotrexate, to which many patients respond very well. However, if they do not respond and no remission ...

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Methotrexate

Methotrexate (rINN) ( /mɛθɵˈtrɛkseɪt/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was developed by Yellapragada Subbarao.

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