Doctors might one day be able to target children and young people with arthritis most likely to be helped by its first-line treatment, thanks to the application of machine learning by University of Manchester scientists.
Jan 16, 2024
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For patients with hand osteoarthritis and synovitis, methotrexate has a potentially clinically meaningful effect on reducing pain, with no increase in adverse events, according to a study published online Oct. 12 in The Lancet.
Nov 6, 2023
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Relief could be on the way for people with painful hand osteoarthritis after a Monash University and Alfred Health-led study found an affordable existing drug can help. Until now there has been no effective treatment.
Oct 13, 2023
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A study led by King's College London compared the safety and efficacy of ciclosporin with methotrexate in children and young people with severe atopic dermatitis, a debilitating skin condition. They also examined whether ...
Sep 19, 2023
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For patients with minimally active or inactive uveitis and persistent or recurrent uveitic macular edema (ME), dexamethasone is significantly better for treatment than methotrexate or ranibizumab, according to a study published ...
Jun 22, 2023
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A major new study has found a method to identify people who may experience blood, kidney, or liver related side effects from methotrexate, the most commonly used immune-suppressing medicine with 1.3 million users in the UK.
May 30, 2023
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For patients with recalcitrant alopecia areata totalis or universalis, methotrexate combined with prednisone yields complete hair regrowth in about 31 percent of patients, according to a study published online March 8 in ...
Mar 15, 2023
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People with rheumatoid arthritis are at increased risk of cardiovascular (CV) disease, with studies indicating an approximate 50 percent increase in risk of CV events such as heart attack and stroke. Some immunomodulators—drugs ...
Dec 5, 2022
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Up to three quarters of patients receiving cancer chemotherapy suffer from "chemo brain"—a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, ...
Sep 13, 2022
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In its final Phase III clinical trial, a new drug for treating rheumatoid arthritis has proved to be at least as effective as the current "gold standard" treatment for this autoimmune disease. This opens up new treatment ...
Aug 25, 2022
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Methotrexate (rINN) ( /mɛθɵˈtrɛkseɪt/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was developed by Yellapragada Subbarao.
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